Anti-Aging

Read More Books to Increase Longevity

Despite the recent popularity of the Kindle and other e-readers, sales of printed books are increasing. In 2015, there were 571 million units sold in the United States, compared to 559 million the previous year. Reading books is a popular way of relaxing and escaping stressful thoughts, as well as passing the time. Reading can also preserve structural integrity in the brain, as people age. Now, it is believed to have the added benefit of helping us to live longer.

Becca R. Levy, a professor of epidemiology at Yale University of Public Health, and her colleagues, analyzed data provided by the Health and Retirement Study (a nationally representative sample of American adults, 50 years of age or older). 3,635 men and women were included in the study, and all self-reported their reading habits. For approximately 12 years, they were followed-up, and their survival was monitored. Those who read books for up to 3.5 hours weekly were 17% less likely to die over the 12 year follow-up, compared to those who did not read books. Those who read for over 3.5 hours per week were 23% less likely to die. Over the course of the 12 years, the adults who read books survived almost 2 years longer than the adults who did not read.

Check the full story.

Source: WorldHealth.net

High Intensity Interval Training (HIIT) Reverses Aging

The Mayo Clinic has determined that intense aerobic exercise has the potential to reverse the aging process in adults. Though everyone knows exercise is beneficial, there are plenty of questions regarding which types of exercises are the best and what age groups benefit the most from specific exercises. According to the Mayo Clinic, high intensity cardio can reverse some cellular aspects of aging.

The Study’s Aim

The purpose of the study described above was to pinpoint evidence that would assist in the development of exercise recommendations and targeted therapies for people of varying ages. Researchers monitored molecular and metabolic alterations in individuals of varying ages across a period of about three months. They collected data 72 hours after those in randomized groups performed an array of different exercises.

Study Details

Mayo Clinic researchers tested high-intensity interval training (HIIT) against combined training and resistance training. Each style of training boosted lean body mass as well as insulin sensitivity. However, HIIT and combined training heightened aerobic capacity as well as mitochondrial functionality for skeletal muscle. This is especially important for senior citizens who often endure declines in mitochondrial content and functionality.

HIIT even boosted muscle protein content that improved energetic functions and spurred the enlargement of muscles. This bolstering of muscle protein was common in older adults who engaged in high-intensity intervals. The research team keyed in on one of their most important findings: exercise boosted the cellular machinery necessary for the construction of new proteins. Protein creation and synthesis reverse some of the problematic effects of the aging process.

The take-home message is that HIIT is ideal for aging adults as it benefits the body at the molecular level as well as metabolically. HIIT reverses certain manifestations of the aging process within the human body’s protein function. Engaging in resistance training is also advisable as it allows for the establishment of considerable muscle strength. HIIT is certainly beneficial yet a strict reliance on this style of exercise won’t significantly boost muscle strength unless combined with resistance training.

Check the full story.

Source: WorldHealth.net

High Levels of Exercise Linked to Nine Years of Less Aging at the Cellular Level

Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can’t stop Old Father Time. But new research from Brigham Young University reveals you may be able to slow one type of aging – the kind that happens inside your cells. As long as you’re willing to sweat.

“Just because you’re 40, doesn’t mean you’re 40 years old biologically,” Tucker said. “We all know people that seem younger than their actual age. The more physically active we are, the less biological aging takes place in our bodies.”

The study, published in the medical journal Preventive Medicine, finds that people who have consistently high levels of physical activity have significantly longer telomeres than those who have sedentary lifestyles, as well as those who are moderately active. Telomeres are the protein endcaps of our chromosomes. They’re like our biological clock and they’re extremely correlated with age; each time a cell replicates, we lose a tiny bit of the endcaps. Therefore, the older we get, the shorter our telomeres.

Exercise science professor Larry Tucker found adults with high physical activity levels have telomeres with a biological aging advantage of nine years over those who are sedentary, and a seven-year advantage compared to those who are moderately active. To be highly active, women had to engage in 30 minutes of jogging per day (40 minutes for men), five days a week.

“If you want to see a real difference in slowing your biological aging, it appears that a little exercise won’t cut it,” Tucker said. “You have to work out regularly at high levels.”

Although the exact mechanism for how exercise preserves telomeres is unknown, Tucker said it may be tied to inflammation and oxidative stress. Previous studies have shown telomere length is closely related to those two factors and it is known that exercise can suppress inflammation and oxidative stress over time.

“We know that regular physical activity helps to reduce mortality and prolong life, and now we know part of that advantage may be due to the preservation of telomeres,” Tucker said.

Check the full story.

Source: ScienceDaily

Scientists Unveil a Giant Leap for Anti-Aging

University of New South Wales, UNSW, researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.

In a paper published in Science today, the team identifies a critical step in the molecular process that allows cells to repair damaged DNA. Their experiments in mice suggest a treatment is possible for DNA damage from ageing and radiation. It is so promising it has attracted the attention of NASA, which believes the treatment can help its Mars mission.

While our cells have an innate capability to repair DNA damage –  which happens every time we go out into the sun, for example – their ability to do this declines as we age.

The scientists identified that the metabolite NAD+, which is naturally present in every cell of our body, has a key role as a regulator in protein-to-protein interactions that control DNA repair. Treating mice with a NAD+ precursor, or “booster,” called NMN improved their cells’ ability to repair DNA damage caused by radiation exposure or old age. “The cells of the old mice were indistinguishable from the young mice, after just one week of treatment,” said lead author Professor David Sinclair of UNSW School of Medical Sciences and Harvard Medical School Boston.

Human trials of NMN therapy will begin within six months. “This is the closest we are to a safe and effective anti-ageing drug that’s perhaps only three to five years away from being on the market if the trials go well,” says Sinclair, who maintains a lab at UNSW in Sydney.

Check the full story.

Source: ScienceDaily

The Quintessential Anti-Aging Essential

Support.Walking.FootprintA mountain of evidence documents that physical inactivity raises a person’s risk of premature death, as well as increases the risks of diseases such as heart disease and cancer. Ulf Ekelund, from, the University of Cambridge (United Kingdom), and colleagues assessed the link between physical inactivity and premature death. The team analyzed data collected on 334,161 men and women across Europe, enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Over an average of 12 years, the researchers measured height, weight and waist circumference, and used self-assessment to measure levels of physical activity.

Data analysis revealed that the greatest reduction in risk of premature death occurred in the comparison between inactive and moderately inactive groups. The investigators estimated that daily exercise burning between 90 and 110 kcal (‘calories’) – roughly equivalent to a 20-minute brisk walk – would take an individual from the inactive to moderately inactive group, and reduce their risk of premature death by between 16-30%. The impact was greatest among normal weight individuals, but even those with higher BMI saw a benefit.

In further calculations, the team reveals that 337,000 of the 9.2 million deaths among European men and women may be attributed to obesity (classed as a BMI greater than 30) – with double this number of deaths (676,000) attributable to physical inactivity. The study authors report that: “The greatest reductions in mortality risk were observed between the 2 lowest activity groups across levels of general and abdominal adiposity, which suggests that efforts to encourage even small increases in activity in inactive individuals may be beneficial to public health.”

Read the full story.

Source: WorldHealth.net

Anti-Aging Tip Sheet: Anti-Aging Essentials

Support.Anti.Aging.PyramidThe goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion. The clinical specialty of anti-aging medicine utilizes diagnostic protocols that are supported by scientific evidence to arrive at an objective assessment upon which effective treatment is assigned. Physicians who dispense anti-aging medical care are concerned with the restoration of optimal functioning of the human body’s systems, organs, tissues, and cells.

Potentially 37 million premature deaths over 15 years may be prevented, simply if people modulated six specific modifiable risk factors. Various countries aim to reduce premature mortality from four main non-communicable diseases (NCDs), namely – cardiovascular diseases, chronic respiratory diseases, cancers, and diabetes. These nations have targeted to reduce these disease incidences by 25% from 2010 levels by 2025. Potentially 37 million premature deaths over 15 years may be prevented, simply if nations adopt the anti-aging medical model. Majid Ezzati from Imperial College London (United Kingdom), and colleagues report that this target may be achievable by the reduction of six specific modifiable risk factors.

Read the full story.

Source: WorldHealth.net

Does Exercise Slow the Aging Process?

Workout.Exercise.Dict2Almost any amount and type of physical activity may slow aging deep within our cells, a new study finds. And middle age may be a critical time to get the process rolling, at least by one common measure of cell aging.

Dating a cell’s age is tricky, because its biological and chronological ages rarely match. A cell could be relatively young in terms of how long it has existed but function slowly or erratically, as if elderly.

Today, many scientists have begun determining a cell’s biological age – meaning how well it functions and not how old it literally is – by measuring the length of its telomeres.

For those of us who don’t know every portion of our cells’ interiors, telomeres are tiny caps found on the end of DNA strands, like plastic aglets on shoelaces. They are believed to protect the DNA from damage during cell division and replication. As a cell ages, its telomeres naturally shorten and fray. But the process can be accelerated by obesity, smoking, insomnia, diabetes and other aspects of health and lifestyle.

A new study, which was published this month in Medicine & Science in Sports & Exercise, researchers from the University of Mississippi and University of California, San Francisco, decided to look broadly at the interactions of exercise and telomeres.

Their results show that risk declined more substantially if someone exercised more. People who reported two types of exercise per week were 24 percent less likely to have short telomeres; three types of exercise were 29 percent less likely; and those who had participated in all four types of activities were 59 percent less likely to have very short telomeres.

Interestingly, these associations were strongest among people between the ages of 40 and 65, the researchers found, suggesting that middle age may be a key time to begin or maintain an exercise program if you wish to keep telomeres from shrinking, says Paul Loprinzi, an assistant professor of health and exercise science at the University of Mississippi.

The message seems clear, Dr. Loprinzi says. “Exercise is good” for your cells, and “more exercise in greater variety” is likely to be even better.

Check the full story.

Source: the New York Times.

A 2-Minute Anti-Aging Activity

Support.Walking.FootprintAmassing published studies show that sitting for extended periods of time each day leads to increased risk for early death, as well as heart disease, diabetes and other health conditions. Emerging data suggests that it is not sufficient to simply replace sitting with standing. Srinivasan Beddhu, from the University of Utah (Utah, USA), and colleagues analyzed data collected in 3,626 men and women enrolled in the National Health and Nutrition Examination Survey, 2003-2004.  The team found that by replacing sitting for 2 minutes each hour with walking for 2 minutes hourly, lowered the risk of dying by 33%.  The study authors submit that: “Interventions that replace sedentary duration with an increase in light activity duration might confer a survival benefit.”

Check the full story.

Source: WorldHealth.net

BioViva Treats First Patient with Gene Therapy to Reverse Aging

Body.OldAge1BioViva USA, Inc. has become the first company to treat a person with gene therapy to reverse biological aging, using a combination of two therapies developed and applied outside the United States of America. Testing and research on these therapies is continuing in BioViva’s affiliated labs worldwide.

BioViva CEO Elizabeth Parrish announced that the subject is doing well and has resumed regular activities. Preliminary results will be evaluated at 5 and 8 months with full outcome expected at 12 months. The patient will then be monitored every year for 8 years.

Gene therapy allows doctors to treat disease at the cellular level by inserting a gene into a patient’s cells instead of using the regular modalities of oral drugs or surgery. BioViva is testing several approaches to age reversal, including using gene therapy to introduce genes into the body.

Check the full story.

Source: prweb.

Lifetime of Fitness: Fountain of Youth for Bone, Joint Health?

Business.Cloud.PhysicalActivity1Being physically active may significantly improve musculoskeletal and overall health, and minimize or delay the effects of aging, according to a review of the latest research on senior athletes (ages 65 and up) appearing in the September issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS).

It long has been assumed that aging causes an inevitable deterioration of the body and its ability to function, as well as increased rates of related injuries such as sprains, strains and fractures; diseases, such as obesity and diabetes; and osteoarthritis and other bone and joint conditions. However, recent research on senior, elite athletes suggests usage of comprehensive fitness and nutrition routines helps minimize bone and joint health decline and maintain overall physical health.

“An increasing amount of evidence demonstrates that we can modulate age-related decline in the musculoskeletal system,” said lead study author and orthopaedic surgeon Bryan G. Vopat, MD. “A lot of the deterioration we see with aging can be attributed to a more sedentary lifestyle instead of aging itself.”

The positive effects of physical activity on maintaining bone density, muscle mass, ligament and tendon function, and cartilage volume are keys to optimal physical function and health. In addition, the literature recommends a combined physical activity regimen for all adults encompassing resistance, endurance, flexibility and balance training, “as safely allowable for a given person.

Read the full story.

Source: American Academy of Orthopaedic Surgeons. “Lifetime of fitness: Fountain of youth for bone, joint health?.” ScienceDaily. ScienceDaily, 27 August 2014.