Anti-Aging

Key Mechanisms of Cancer, Aging and Inflammation Revealed

Body.OldAge1A team of researchers from the University of Pittsburgh, lead by Patricia Opresko, Ph.D have discovered crucial new information about telomeres, the end caps of DNA. Telomeres (repeated sequences of DNA) are shortened each time a cell divides, thus becoming smaller with age. When telomeres become too short, they send a signal to the cell to cease dividing permanently – this impairs the ability of tissues to regenerate, contributing to various age-related diseases.

In cancer cells, on the other hand, levels of the enzyme telomerase (which lengthens telomeres) are elevated. This enables them to divide indefinitely. “The new information will be useful in designing new therapies to preserve telomeres in healthy cells and ultimately help combat the effects of inflammation and aging. On the flip side, we hope to develop mechanisms to selectively deplete telomeres in cancer cells to stop them from dividing,” said Dr. Opresko.

Previous studies have shown that oxidative stress accelerates telomere shortening. Oxidative stress is a condition where free radicals build up inside the cell, causing damage. Free radicals can damage the DNA that makes up the telomeres, as well as the DNA building blocks used to extend them. Oxidative stress also plays a role in various other health conditions, including cancer and inflammation. Free radical damage, which is often caused by inflammation in the body, as well as environmental factors, is believed to build up throughout the aging process.

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Source: WorldHealth.net.

High Levels of Exercise Linked to Nine Years of Less Aging at the Cellular Level

Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can’t stop Old Father Time. But new research from Brigham Young University reveals you may be able to slow one type of aging – the kind that happens inside your cells. As long as you’re willing to sweat.

“Just because you’re 40, doesn’t mean you’re 40 years old biologically,” Tucker said. “We all know people that seem younger than their actual age. The more physically active we are, the less biological aging takes place in our bodies.”

The study, published in the medical journal Preventive Medicine, finds that people who have consistently high levels of physical activity have significantly longer telomeres than those who have sedentary lifestyles, as well as those who are moderately active. Telomeres are the protein endcaps of our chromosomes. They’re like our biological clock and they’re extremely correlated with age; each time a cell replicates, we lose a tiny bit of the endcaps. Therefore, the older we get, the shorter our telomeres.

Exercise science professor Larry Tucker found adults with high physical activity levels have telomeres with a biological aging advantage of nine years over those who are sedentary, and a seven-year advantage compared to those who are moderately active. To be highly active, women had to engage in 30 minutes of jogging per day (40 minutes for men), five days a week.

“If you want to see a real difference in slowing your biological aging, it appears that a little exercise won’t cut it,” Tucker said. “You have to work out regularly at high levels.”

Although the exact mechanism for how exercise preserves telomeres is unknown, Tucker said it may be tied to inflammation and oxidative stress. Previous studies have shown telomere length is closely related to those two factors and it is known that exercise can suppress inflammation and oxidative stress over time.

“We know that regular physical activity helps to reduce mortality and prolong life, and now we know part of that advantage may be due to the preservation of telomeres,” Tucker said.

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Source: ScienceDaily

Scientists Unveil a Giant Leap for Anti-Aging

University of New South Wales, UNSW, researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.

In a paper published in Science today, the team identifies a critical step in the molecular process that allows cells to repair damaged DNA. Their experiments in mice suggest a treatment is possible for DNA damage from ageing and radiation. It is so promising it has attracted the attention of NASA, which believes the treatment can help its Mars mission.

While our cells have an innate capability to repair DNA damage –  which happens every time we go out into the sun, for example – their ability to do this declines as we age.

The scientists identified that the metabolite NAD+, which is naturally present in every cell of our body, has a key role as a regulator in protein-to-protein interactions that control DNA repair. Treating mice with a NAD+ precursor, or “booster,” called NMN improved their cells’ ability to repair DNA damage caused by radiation exposure or old age. “The cells of the old mice were indistinguishable from the young mice, after just one week of treatment,” said lead author Professor David Sinclair of UNSW School of Medical Sciences and Harvard Medical School Boston.

Human trials of NMN therapy will begin within six months. “This is the closest we are to a safe and effective anti-ageing drug that’s perhaps only three to five years away from being on the market if the trials go well,” says Sinclair, who maintains a lab at UNSW in Sydney.

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Source: ScienceDaily

Benchmark Database of Lifespan-Extending Drugs Announced

Scientists from the Biogerontology Research Foundation (BGRF) and University of Liverpool have announced a landmark database of lifespan-extending drugs and compounds called DrugAge. The database has 418 compounds, curated from studies spanning 27 different model organisms including yeast, worms, flies and mice. It is the largest such database in the world at this time. Significantly, the study found that the majority of age-related pathways have not yet been targeted pharmacologically, and that the pharmacological modulation of aging has by and large focused upon a small subset of currently known age-related pathways. This suggests that there is still plenty of scope for the discovery of new lifespan-extending and healthspan-extending compounds.

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Source: Yael.

Getting Stronger to Live Longer

Workout.Female.DumbellBetween the age of 30 and 70, the average person will have lost about a quarter of their muscle strength. Half will be lost by the age of 90. As crucial as it is to promoting overall health and warding off disease, aerobic exercise alone is not enough to forestall this. Without the inclusion of strength training, muscles become progressively weaker, as well as less functional. Strength training can enable people over the age of 50 to live longer, more quality lives.

Beginning a strength training regimen takes as little as twenty minutes per session and does not require excessive stress or straining. The key is to use proper form, in a consistent manner, tackling both upper and lower body muscles. Noticeable strength gains can be realized in as little as four weeks. Methods of strength training include the use of free weights, ankle cuffs and vests, resistance bands, and exercises that employ body weight to create resistance against gravity. A slow pace starting off is important, in order to avoid injury.

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Source: WorldHealth.net

Anti-Aging Tip Sheet: Anti-Aging Essentials

Support.Anti.Aging.PyramidThe goal of anti-aging medicine is not to merely prolong the total years of an individual’s life, but to ensure that those years are enjoyed in a productive and vital fashion. The clinical specialty of anti-aging medicine utilizes diagnostic protocols that are supported by scientific evidence to arrive at an objective assessment upon which effective treatment is assigned. Physicians who dispense anti-aging medical care are concerned with the restoration of optimal functioning of the human body’s systems, organs, tissues, and cells.

Potentially 37 million premature deaths over 15 years may be prevented, simply if people modulated six specific modifiable risk factors. Various countries aim to reduce premature mortality from four main non-communicable diseases (NCDs), namely – cardiovascular diseases, chronic respiratory diseases, cancers, and diabetes. These nations have targeted to reduce these disease incidences by 25% from 2010 levels by 2025. Potentially 37 million premature deaths over 15 years may be prevented, simply if nations adopt the anti-aging medical model. Majid Ezzati from Imperial College London (United Kingdom), and colleagues report that this target may be achievable by the reduction of six specific modifiable risk factors.

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Source: WorldHealth.net

Does Exercise Slow the Aging Process?

Workout.Exercise.Dict2Almost any amount and type of physical activity may slow aging deep within our cells, a new study finds. And middle age may be a critical time to get the process rolling, at least by one common measure of cell aging.

Dating a cell’s age is tricky, because its biological and chronological ages rarely match. A cell could be relatively young in terms of how long it has existed but function slowly or erratically, as if elderly.

Today, many scientists have begun determining a cell’s biological age – meaning how well it functions and not how old it literally is – by measuring the length of its telomeres.

For those of us who don’t know every portion of our cells’ interiors, telomeres are tiny caps found on the end of DNA strands, like plastic aglets on shoelaces. They are believed to protect the DNA from damage during cell division and replication. As a cell ages, its telomeres naturally shorten and fray. But the process can be accelerated by obesity, smoking, insomnia, diabetes and other aspects of health and lifestyle.

A new study, which was published this month in Medicine & Science in Sports & Exercise, researchers from the University of Mississippi and University of California, San Francisco, decided to look broadly at the interactions of exercise and telomeres.

Their results show that risk declined more substantially if someone exercised more. People who reported two types of exercise per week were 24 percent less likely to have short telomeres; three types of exercise were 29 percent less likely; and those who had participated in all four types of activities were 59 percent less likely to have very short telomeres.

Interestingly, these associations were strongest among people between the ages of 40 and 65, the researchers found, suggesting that middle age may be a key time to begin or maintain an exercise program if you wish to keep telomeres from shrinking, says Paul Loprinzi, an assistant professor of health and exercise science at the University of Mississippi.

The message seems clear, Dr. Loprinzi says. “Exercise is good” for your cells, and “more exercise in greater variety” is likely to be even better.

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Source: the New York Times.

A 2-Minute Anti-Aging Activity

Support.Walking.FootprintAmassing published studies show that sitting for extended periods of time each day leads to increased risk for early death, as well as heart disease, diabetes and other health conditions. Emerging data suggests that it is not sufficient to simply replace sitting with standing. Srinivasan Beddhu, from the University of Utah (Utah, USA), and colleagues analyzed data collected in 3,626 men and women enrolled in the National Health and Nutrition Examination Survey, 2003-2004.  The team found that by replacing sitting for 2 minutes each hour with walking for 2 minutes hourly, lowered the risk of dying by 33%.  The study authors submit that: “Interventions that replace sedentary duration with an increase in light activity duration might confer a survival benefit.”

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Source: WorldHealth.net

BioViva Treats First Patient with Gene Therapy to Reverse Aging

Body.OldAge1BioViva USA, Inc. has become the first company to treat a person with gene therapy to reverse biological aging, using a combination of two therapies developed and applied outside the United States of America. Testing and research on these therapies is continuing in BioViva’s affiliated labs worldwide.

BioViva CEO Elizabeth Parrish announced that the subject is doing well and has resumed regular activities. Preliminary results will be evaluated at 5 and 8 months with full outcome expected at 12 months. The patient will then be monitored every year for 8 years.

Gene therapy allows doctors to treat disease at the cellular level by inserting a gene into a patient’s cells instead of using the regular modalities of oral drugs or surgery. BioViva is testing several approaches to age reversal, including using gene therapy to introduce genes into the body.

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Source: prweb.

Three Key Anti-Aging Lifestyles

Body.OldAge2The protective endcaps of chromosomes that affect how quickly cells age, telomeres are combinations of DNA and proteins that protect the ends of chromosomes and help them remain stable. Telomere shortening is associated with a weakening of structural integrity, and is thought to be a mechanism of aging.

Eli Puterman, from the University of California/San Francisco (UCSF; California, USA), and colleagues examined three healthy behaviors, namely – physical activity, dietary intake and sleep quality – over the course of one year in 239 post-menopausal, non-smoking women. The women provided blood samples at the beginning and end of the year for telomere measurement and reported on stressful events that occurred during those 12 months.

In women who engaged in lower levels of healthy behaviors, there was a significantly greater decline in telomere length in their immune cells for every major life stressor that occurred during the year. Yet women who maintained active lifestyles, healthy diets, and good quality sleep appeared protected when exposed to stress – accumulated life stressors did not appear to lead to greater shortening.

Observing that: “Women who maintained relatively higher levels of health behaviors (1  standard deviation above the mean) appeared to be protected when exposed to stress,” the study authors submit that: “This finding has implications for understanding malleability of telomere length, as well as expectations for possible intervention effects.”

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Source: WorldHealth.net