Supplement

NAD+ and Cellular Aging: Breaking Down the Research
NAD+ (nicotinamide adenine dinucleotide) is a molecule at the heart of cellular energy production and repair. As we age, our NAD+ levels decline—impacting metabolism, DNA repair, and resilience against age-related disease. Here’s what the latest science says about NAD+, aging, and what you can do about it.

What Is NAD+?

  • Cellular Currency: NAD+ is required for turning food into energy, repairing DNA, and regulating cell survival.
  • Declines With Age: NAD+ levels drop steadily after age 40, contributing to age-related metabolic and degenerative changes.

How NAD+ Impacts Aging

  • DNA Repair: NAD+ fuels enzymes (sirtuins, PARPs) that repair cellular damage and support genomic stability.
  • Metabolic Health: Higher NAD+ supports mitochondrial function, muscle health, and insulin sensitivity.
  • Neuroprotection: Animal studies show NAD+ boosts brain resilience and may protect against neurodegeneration.

Science Spotlight

  • Human Trials: Supplementing with NAD+ precursors (NR, NMN) increases NAD+ levels, but evidence for clinical benefits is still emerging (Lifespan.io, 2023).
  • Animal Research: Raising NAD+ in mice delays aging markers and extends lifespan (NCBI, 2018).
  • Safety: Current data suggests NAD+ precursors are safe for most, but long-term effects are unknown.

References & Sources

Disclaimer: Club One Fifty provides information for educational purposes only. This content is not medical advice. Always consult a healthcare professional before starting any new supplement or making significant lifestyle changes.

Longevity Supplements: What Science Actually Supports
The supplement industry is booming with promises of a longer, healthier life—but what does the science really say? Let’s cut through the hype and focus on supplements with actual evidence for supporting longevity and healthy aging.

Supplements with the Strongest Evidence

  • Vitamin D: Essential for bone, immune, and metabolic health. Deficiency is common, especially in northern climates. Supplementation is linked to lower mortality and reduced risk of age-related diseases in those with low levels.
  • Omega-3 Fatty Acids (EPA/DHA): Shown to reduce cardiovascular risk, support brain health, and lower inflammation. Best sourced from fatty fish or high-quality supplements.
  • Magnesium: Important for muscle, nerve, and heart health. Supports sleep quality and may reduce the risk of chronic disease.
  • Probiotics: Support gut microbiome diversity and may reduce inflammation, though benefits are strain-specific and best paired with a fiber-rich diet.
  • Creatine: Well-studied for muscle health and cognitive support in older adults.

Supplements with Emerging or Mixed Evidence

  • Nicotinamide Riboside (NR) & NMN: Boost NAD+ levels, which decline with age. Animal studies are promising, but human data is still limited.
  • Resveratrol & Polyphenols: Antioxidants found in red wine and certain plants. Some evidence for cardiovascular and metabolic benefits, but effects in humans are modest.
  • Berberine: May help regulate blood sugar and cholesterol, but long-term safety data is limited.
  • Curcumin: The active compound in turmeric, with anti-inflammatory properties. Bioavailability can be an issue.

Supplements to Approach with Caution

  • High-dose antioxidants (vitamin E, beta-carotene) have not shown consistent longevity benefits and may be harmful in excess.
  • Unregulated or “anti-aging” blends often lack evidence and can interact with medications.

Science Spotlight

  • Vitamin D & Mortality: Meta-analyses show reduced all-cause mortality in deficient individuals who supplement (ScienceDaily, 2021).
  • Omega-3s & Longevity: Higher blood omega-3 levels are associated with longer life expectancy and lower cardiovascular risk (NCBI, 2018).
  • NR/NMN & Aging: Human studies show increased NAD+ levels, but clinical benefits for longevity are not yet established (Lifespan.io, 2023).

References & Sources

Disclaimer: Club One Fifty provides information for educational purposes only. This content is not medical advice. Always consult a healthcare professional before starting any new supplement.