NAD+ (nicotinamide adenine dinucleotide) is a molecule at the heart of cellular energy production and repair. As we age, our NAD+ levels decline—impacting metabolism, DNA repair, and resilience against age-related disease. Here’s what the latest science says about NAD+, aging, and what you can do about it.

What Is NAD+?

• Cellular Currency: NAD+ is required for turning food into energy, repairing DNA, and regulating cell survival.
• Declines With Age: NAD+ levels drop steadily after age 40, contributing to age-related metabolic and degenerative changes.

How NAD+ Impacts Aging

• DNA Repair: NAD+ fuels enzymes (sirtuins, PARPs) that repair cellular damage and support genomic stability.
• Metabolic Health: Higher NAD+ supports mitochondrial function, muscle health, and insulin sensitivity.
• Neuroprotection: Animal studies show NAD+ boosts brain resilience and may protect against neurodegeneration.

Science Spotlight

• Human Trials: Supplementing with NAD+ precursors (NR, NMN) increases NAD+ levels, but evidence for clinical benefits is still emerging (Lifespan.io, 2023).
• Animal Research: Raising NAD+ in mice delays aging markers and extends lifespan (NCBI, 2018).
• Safety: Current data suggests NAD+ precursors are safe for most, but long-term effects are unknown.

References & Sources

• Lifespan.io: NAD+ Precursors and Aging (2023)
• NCBI: NAD+ in Aging (2018)
• ScienceDaily: NAD+ and Cellular Health (2022)
• Fight Aging: NAD+ and Aging